(Dichloromethylene)bis(phosphonic acid)
CLODRONIC ACID
CAS: 10596-23-3
Molecular Formula: CH4Cl2O6P2
(Dichloromethylene)bis(phosphonic acid) - Names and Identifiers
(Dichloromethylene)bis(phosphonic acid) - Physico-chemical Properties
| Molecular Formula | CH4Cl2O6P2 |
| Molar Mass | 244.892 |
| Density | 2.306±0.06 g/cm3(Predicted) |
| Melting Point | 249-251° |
| Boling Point | 474.7±55.0 °C(Predicted) |
| pKa | 0.75±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Use | Chlordronic acid is an organic compound, suitable for bone metastasis cancer, multiple myeloma, (Paget's disease) and osteoporosis caused by various reasons; treatment of hypercalcemia caused by malignant tumors; treatment Osteoporosis. |
(Dichloromethylene)bis(phosphonic acid) - Purification method
A method for refining and purifying disodium clodronate, the method comprising the following steps:
S1:EDTA treatment of activated carbon
Add the activated carbon to the EDTA solution, stir to make the EDTA fully contact with the activated carbon, and then wash the activated carbon until there is no chloride detection;
S2: activated carbon
Dry the activated carbon in S1 and activate it;
S3: activated carbon impurity removal
Use the activated carbon in S2 to treat the crude product solution of disodium chlorophosphate, filter, wash and control the pH of the filtrate not to exceed 3.65;
S4: crystallization and drying
Ethanol is added to the filtrate of S3 while stirring. After white crystals are precipitated, the refined product of disodium chlorophosphate is obtained by standing, filtering and drying.
Last Update：2024-04-10 22:29:15
(Dichloromethylene)bis(phosphonic acid) - Production method
Triisopropyl phosphonite and dibromomethane are heated and refluxed under stirring to evaporate the unreactants to obtain oily tetraisopropyl methane diphosphonate. Add it to the sodium hypochlorite solution, react, and then use chloroform to extract three times, merge the chloroform solution, evaporate most of the chloroform under reduced pressure, and cool out a white solid, which is dichloromethane diphosphonic acid tetraisopropyl ester. Add it to 1,1,2,2, 2-tetrachloroethane, heat and reflux, and evaporate 1,1,2,2, 2-tetrachloroethane under reduced pressure to obtain
The oil is recrystallized with isopropyl ether/chloroform to obtain chlorophosphonic acid.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: CLODRONIC ACID Visit Supplier Webpage Request for quotationCAS: 10596-23-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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